ABSTRACT
Background: Carcinoma of the breast is a leading cause of death in women and needs to be evaluated at an early stage. FNAC helps in rapid diagnosis of breast lesions and their management. Objective: To study the diagnostic efficacy of FNAC in breast lesions. Materials and methods: Three year retrospective study of 105 cases of breast lump was conducted which included cases, where FNAC and histopathological correlation was available. The cytological diagnosis was classified as inflammatory lesions, benign, atypical probably benign, suspicious for malignancy and malignant. Results: On cytology out of 105 cases, 57 were benign, 7 inflammatory lesions, 34 malignant and 7 were inadequate. Fibroadenoma was the most common benign lesion noted in age group of 21-30 years and infiltrating ductal carcinoma was the most common malignant lesion in 31-40 years age group. Diagnostic accuracy, sensitivity and specificity of this study were 96.93%, 91.89% and 100% respectively. Conclusion: FNAC of breast lesions is a simple, safe and effective modality in pre-operative assessment of benign and malignant lesions and shows high accuracy, sensitivity and specificity.
ABSTRACT
Introduction: Breast carcinoma is the most common malignancy and the leading cause of death in women. Fine needle aspiration cytology (FNAC) plays a critical role in early diagnosis of any palpable breast lump. Aim and objectives: The aim of the study was to find out the utility of grading malignant breast tumours using Robinson’s cytology grading on FNAC and correlating it with Modified Bloom Richardson grading along with lymph node status assessment post-operatively by histopathological examination. Materials and methods: A retrospective study was conducted; cytological smears of 30 cases of breast carcinomas on FNAC were graded according to the Robinson’s cytology grading and correlated with Modified Bloom Richardson histopathological grading system over a period of 1 year. Results: There were a total of 28 (93.33%) cases of invasive ductal carcinoma, 1 case of mucinous carcinoma and 1 case of Metaplastic carcinoma. All patients were females with a mean age of 52.8 years. The correlation showed 85.71% concordance between the two grading systems with a 93.33% agreement and an observed weighted Kappa value of 0.916 implying a substantial strength of agreement. Chi-square statistical test performed for lymph node metastasis with grade of the tumor was statistically significant with a p-value of 0.0189 (p<0.05). Agarwal AA, Tambekar MY, Dhar R. Fine Needle Aspiration Cytology of Breast Carcinoma: A Comparative Study between Cytological and Histopathological Grading System with Lymph Node Status Assessment. IAIM, 2016; 3(10): 27-35. Page 28 Conclusion: Cytological grading of malignant breast carcinoma aspirates will help in the management and planning future treatment including preoperative neoadjuvant chemotherapy. We recommend it to be followed by all cytopathologists, in order to bring uniformity in the reporting of breast FNAs for grading the malignant lesions.